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KMID : 0644319990050010019
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Journal of Korean Oriental Oncology
1999 Volume.5 No. 1 p.19 ~ p.32
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Study on Antitumor Activity and Antimetastatic effect of Kamigumguesingihwan(KGSH)
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Abstract
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To evaluate the antitumor activity and antimetastatic effats of Kamigumgusingihwan(KGSH) studies have ken dom.
The results were obtained as follows:
1. KGSH extras exhibited a weak cytotoxicity against A549, SK-OV-3, B16-F10, and SK-MEL-2 cell lines. But exhibited potent cytotoxicity against P388 cell line in a dose-dpendent manner.
2. The concentration inhibiting adhesion of A549 to complex extracellular maMx up to below 30% of control was recognized at 10^-3g/ml of KGSH
3. KGSH extrats showed a wed inhibitoty effect on DNA topo- isomerase I from calf thyus.
4. The T/C% wa 137% in KGSH treated group in S-180 bearing ICR mice.
5. In pulmonary colonization assay. a number of colonies in the lungs were decreased sigruncanny in KGSH treated group as compared with control group.
6. In hematological changes in Bl6-BL6 injected C57BL/6, numbers of WBC were decreased insignificantly in KGSH treated groups, and also those of platelet were inoeased insignificantly in KGSH treated groups as compared with control.
7. In CAM asay, KGSH extracts inhibited angiogenesis at 15ug/egg concentration significantly as compared with control.
Taken together these results, it is strongly demonstrated that KGSH significantly suppressed tumor metastasis by blpcking cell adheion to exuaalula matrix. Therefore. KGSH is expected to be clinically a potem antimetastatic drug for the prevention and treatment of cancer.
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KEYWORD
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